Another Hypotensive Agent--Methyldopa
نویسندگان
چکیده
منابع مشابه
Ecolid: a new hypotensive agent.
During the past five years ganglion-blocking agents have been used extensively in the treatment of arterial hypertension. The discovery of the activity of hexamethonium by Paton and Zaimis (1949) placed at our disposal an active therapeutic agent capable of producing a substantial reduction in the blood pressure. Subsequent research has been directed to the synthesis of new drugs offering advan...
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AHLQUIST (1948) suggested that adrenergic activity is divisible into alpha and beta groups. The former is concerned mainly with contraction of smooth muscle, including vasoconstriction in some areas-noradrenaline is almost exclusively an alpha substance. The latter includes adrenergic effects on the heart and relaxation of bronchial muscles-isoprenalin restricts itself almost entirely to such a...
متن کاملBulbospinal serotonin pressor pathways and hypotensive action of methyldopa in the rat.
The administration of methyldopa (200 mg/kg i.p.) induced a green fluorescence typical of catecholamine fluorescence, in regions of the brain stem which coincided with all the major serotonin cell groups, including the B1, B2, and B3 cell groups in the medulla. Prior administration of 5,7-dihydroxytryptamine (5,7-DHT), a neurotoxin relatively specific for serotonin neurons, prevented the appear...
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Clonidine (Catapres, Catapresan), guanfacine (Estulic), and methyldopa (Aldomet) are the prototypes of centrally acting antihypertensive drugs. Clonidine and guanfacine are lipophilic drugs that readily penetrate into the brain, where they stimulate alpha-adrenergic receptors in the pontomedullary region. The stimulation of these central alpha-adrenergic receptors has been shown to activate an ...
متن کاملEvidence for a Predominantly Central Hypotensive Effect of a-Methyldopa in Humans
We examined the time course and extent to which central and peripheral mechanisms contribute to the short-term effects of a 500-mg oral dose of a-methyldopa on supine mean arterial pressure, cardiac output, and total peripheral resistance, as well as its effects on total urinary excretion of norepinephrine and its metabolites, in five subjects with essential hypertension. Total peripheral resis...
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ژورنال
عنوان ژورنال: BMJ
سال: 1962
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5298.156